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Article

Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice.

Scientific reports - 27 Jun 2017

Nam Kyong Nyon, Mounier Anais, Wolfe Cody M, Fitz Nicholas F, Carter Alexis Y, Castranio Emilie L, Kamboh Hafsa I, Reeves Valerie L, Wang Jianing, Han Xianlin, Schug Jonathan, Lefterov Iliya, Koldamova Radosveta

Abstract excerpt

We examined the effect of chronic high fat diet (HFD) on amyloid deposition and cognition of 12-months old APP23 mice, and correlated the phenotype to brain transcriptome and lipidome. HFD significantly increased amyloid plaques and worsened cognitive performance compared to mice on normal diet (ND). RNA-seq results revealed that in HFD mice there was an increased expression of genes related to immune response,...

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Share to Amyloid beta-Peptides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28655926
DOI: 10.1038/s41598-017-04412-2
PMCID: PMC5487356

Genes

TREM2

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