Article

CoREST has a conserved role in facilitating SPR-5/LSD1 maternal reprogramming of histone methylation

2021-05-17

Abstract excerpt

<h4>ABSTRACT</h4> Maternal reprogramming of histone methylation is critical for reestablishing totipotency in the zygote, but how histone modifying enzymes are regulated during maternal reprogramming is not well characterized. To address this gap, we asked whether maternal reprogramming by the H3K4me1/2 demethylase SPR-5/LSD1/KDM1A, is regulated by the co-repressor protein, SPR-1/CoREST in C. elegans and mice. I...

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Literature Corpus work: 5b263368-01ef-53fc-b7ec-f354b8288646
DOI: 10.1101/2021.05.17.444472

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