Article

Abnormal behavior is reversible in a chromatin mutant

2023-11-01

Abstract excerpt

How mutations in histone modifying enzymes lead to neurodevelopmental disorders is unknown. We took advantage of the invariant embryonic lineage and adult nervous system in C. elegans to investigate a double mutant between spr-5/Lsd1/Kdm1a (H3K4me1/2 demethylase) and met-2/Setdb1 (H3K9 methyltransferase). We demonstrate that spr-5; met-2 double mutant worms have a severe chemotaxis defect caused by the ectopic...

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Literature Corpus work: 37a116e4-02c9-595e-b53a-213efe2d6a29
DOI: 10.1101/2023.10.29.564525

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