Article
Regulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in C. elegans.
Science advances - 20 Jun 2025
Kirshner Jessica A, Picard Colette L, Weiser Natasha E, Mehta Nicita, Feng Suhua, Murphy Victoria N, Vakhnovetsky Anna, Alessi Amelia F, Xiao Connie, Inoki Kai, El Mouridi Sonia, Frøkjær-Jensen Christian, Jacobsen Steven E, Kim John K
Abstract excerpt
The Argonaute CSR-1 is essential for germline development in C. elegans. Loss of CSR-1 leads to the down-regulation of thousands of germline-expressed genes, supporting a model in which CSR-1 "licenses" gene expression via a poorly understood mechanism. In contrast, a small subset of genes is up-regulated in csr-1 mutants, including morc-1, which encodes a conserved GHKL-type ATPase. We show that morc-1 is...
Topics
- Animals
- Caenorhabditis elegans Proteins
- Caenorhabditis elegans
- Germ Cells
- Mutation
- Chromatin
- Gene Expression Regulation, Developmental
- Histones
- Adenosine Triphosphatases