Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SPR-1/CoREST facilitates the maternal epigenetic reprogramming of the histone demethylase SPR-5/LSD1

19 Jan 2023

Abstract excerpt

Maternal reprogramming of histone methylation is critical for reestablishing totipotency in the zygote, but how histone-modifying enzymes are regulated during maternal reprogramming is not well characterized. To address this gap, we asked whether maternal reprogramming by the H3K4me1/2 demethylase SPR-5/LSD1/KDM1A, is regulated by the chromatin co-repressor protein, SPR-1/CoREST, in Caenorhabditis elegans and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36655746
DOI: 10.1093/genetics/iyad005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SPR-1/CoREST facilitates the maternal epigenetic reprogramming of the histone demethylase SPR-5/LSD1PMID 36655746Read ↗

CoREST has a conserved role in facilitating SPR-5/LSD1 maternal reprogramming of histone methylationSemantic proximity Read ↗

The Dream and MEC NuRD Complexes reinforce SPR-5/MET-2 maternal reprogramming to maintain the germline-soma distinctionSemantic proximity Read ↗

LET-418/Mi2 and SPR-5/LSD1 cooperatively prevent somatic reprogramming of C. elegans germline stem cells.Semantic proximity Read ↗

Caenorhabditis elegans establishes germline versus soma by balancing inherited histone methylationSemantic proximity Read ↗

A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory.Semantic proximity Read ↗

<i>C. elegans</i> establishes germline versus soma by balancing inherited histone methylationSemantic proximity Read ↗

Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatallySemantic proximity Read ↗

SPR-5 is a histone H3K4 demethylase with a role in meiotic double-strand break repair.Semantic proximity Read ↗

Regulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in C. elegans.Semantic proximity Read ↗

AMX-1 is necessary for proper fertility and lack of its expression induced sterility in a p53/CEP-1 dependent manner by modulating piwi expression in C. elegansSemantic proximity Read ↗

MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality.Semantic proximity Read ↗

Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.