Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LET-418/Mi2 and SPR-5/LSD1 cooperatively prevent somatic reprogramming of C. elegans germline stem cells.

Stem cell reports - 8 Apr 2014

Käser-Pébernard Stéphanie, Müller Fritz, Wicky Chantal

Abstract excerpt

Throughout their journey to forming new individuals, germline stem cells must remain totipotent, particularly by maintaining a specific chromatin structure. However, the place epigenetic factors occupy in this process remains elusive. So far, "sensitization" of chromatin by modulation of histone arrangement and/or content was believed to facilitate transcription-factor-induced germ cell reprogramming. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Cellular Reprogramming

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to Germ Cells

Share to Histones

Share to Methylation

Share to Neoplasms, Germ Cell and Embryonal

Share to Oxidoreductases, N-Demethylating

Source

Open in PubMed Open full text

Identifiers

PMID: 24749077
DOI: 10.1016/j.stemcr.2014.02.007
PMCID: PMC3986580

Genes

SPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LET-418/Mi2 and SPR-5/LSD1 cooperatively prevent somatic reprogramming of C. elegans germline stem cells.PMID 24749077Read ↗

A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory.Semantic proximity Read ↗

CoREST has a conserved role in facilitating SPR-5/LSD1 maternal reprogramming of histone methylationSemantic proximity Read ↗

<i>C. elegans</i> establishes germline versus soma by balancing inherited histone methylationSemantic proximity Read ↗

SPR-1/CoREST facilitates the maternal epigenetic reprogramming of the histone demethylase SPR-5/LSD1Semantic proximity Read ↗

Caenorhabditis elegans establishes germline versus soma by balancing inherited histone methylationSemantic proximity Read ↗

Antagonism between MES-4 and Polycomb repressive complex 2 promotes appropriate gene expression in C. elegans germ cells.Semantic proximity Read ↗

Epigenetic dynamics during germline development: insights from Drosophila and C. elegansSemantic proximity Read ↗

AMX-1 is necessary for proper fertility and lack of its expression induced sterility in a p53/CEP-1 dependent manner by modulating piwi expression in C. elegansSemantic proximity Read ↗

Maternal H3K36 and H3K27 HMTs protect germline immortality via regulation of the transcription factor LIN-15BSemantic proximity Read ↗

SPR-5 is a histone H3K4 demethylase with a role in meiotic double-strand break repair.Semantic proximity Read ↗

Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neuronsSemantic proximity Read ↗

The <i>Drosophila</i> histone methyl-transferase SET1 coordinates multiple signaling pathways in regulating male germline stem cell maintenance and differentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.