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Article

MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality.

Developmental cell - 22 May 2017

Weiser Natasha E, Yang Danny X, Feng Suhua, Kalinava Natallia, Brown Kristen C, Khanikar Jayshree, Freeberg Mallory A, Snyder Martha J, Csankovszki Györgyi, Chan Raymond C, Gu Sam G, Montgomery Taiowa A, Jacobsen Steven E, Kim John K

Abstract excerpt

Germline-expressed endogenous small interfering RNAs (endo-siRNAs) transmit multigenerational epigenetic information to ensure fertility in subsequent generations. In Caenorhabditis elegans, nuclear RNAi ensures robust inheritance of endo-siRNAs and deposition of repressive H3K9me3 marks at target loci. How target silencing is maintained in subsequent generations is poorly understood. We discovered that morc-1 is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28535375
DOI: 10.1016/j.devcel.2017.04.023
PMCID: PMC5527976

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MET

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MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality.PMID 28535375Read ↗

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