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Article

A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory.

Cell - 17 Apr 2009

Katz David J, Edwards T Matthew, Reinke Valerie, Kelly William G

Abstract excerpt

Epigenetic information undergoes extensive reprogramming in the germline between generations. This reprogramming may be essential to establish a developmental ground state in the zygote. We show that mutants in spr-5, the Caenorhabditis elegans ortholog of the H3K4me2 demethylase LSD1/KDM1, exhibit progressive sterility over many generations. This sterility correlates with the misregulation of...

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Identifiers

PMID: 19379696
DOI: 10.1016/j.cell.2009.02.015
PMCID: PMC2672044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory.PMID 19379696Read ↗

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