Article

AMX-1 is necessary for proper fertility and lack of its expression induced sterility in a p53/CEP-1 dependent manner by modulating piwi expression in C. elegans

2022-02-25

Abstract excerpt

<title>Abstract</title> Background Histone methylation shapes the epigenetic configuration and adjusts multiple fundamental nuclear processes, including transcription, cell cycle control and DNA repair. The absence of histone demethylase LSD1/SPR-5 leads to progressive fertility defects as well as a reduction in brood size. Similarly, <italic>C. elegans</italic> LSD2 homolog AMX-1 has been implicated in regul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0aafe923-1899-5aa6-8fff-6f6bd57a96c6
DOI: 10.21203/rs.3.rs-1371441/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AMX-1 is necessary for proper fertility and lack of its expression induced sterility in a p53/CEP-1 dependent manner by modulating piwi expression in C. elegansDOI 10.21203/rs.3.rs-1371441/v1Read

Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 are required for maintaining histone methylation levels and interact with the histone demethylase LSD1/SPR-5 in C. elegansSemantic proximity Read

A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory.Semantic proximity Read

The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline.Semantic proximity Read

MORC-1 is a key component of the C. elegans CSR-1 germline gene licensing mechanismSemantic proximity Read

The zinc-finger transcription factor LSL-1 is a major regulator of the germline transcriptional program in C. elegansSemantic proximity Read

LET-418/Mi2 and SPR-5/LSD1 cooperatively prevent somatic reprogramming of C. elegans germline stem cells.Semantic proximity Read

The C. elegans SET-2 histone methyltransferase maintains germline fate by preventing progressive transcriptomic deregulation across generationsSemantic proximity Read

ATRX safeguards cellular identity during C. elegans developmentSemantic proximity Read

MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality.Semantic proximity Read

WDR-5 exhibits H3K4 methylation-independent activity during embryonic development in C. elegansSemantic proximity Read

Regulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in C. elegans.Semantic proximity Read

Epigenetic dynamics during germline development: insights from Drosophila and C. elegansSemantic proximity Read