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Caenorhabditis elegans establishes germline versus soma by balancing inherited histone methylation

18 Jan 2021

Abstract excerpt

ABSTRACT Formation of a zygote is coupled with extensive epigenetic reprogramming to enable appropriate inheritance of histone methylation and prevent developmental delays. In Caenorhabditis elegans, this reprogramming is mediated by the H3K4me2 demethylase SPR-5 and the H3K9 methyltransferase, MET-2. In contrast, the H3K36 methyltransferase MES-4 maintains H3K36me2/3 at germline genes between generations to...

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PMID: 33462111
DOI: 10.1242/dev.196600

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