Article

Allelic expression imbalance of <i>PIK3CA</i> mutations is frequent in breast cancer and prognostically significant

2021-03-06

Abstract excerpt

PIK3CA mutations are the most common in breast cancer, particularly in the estrogen receptor positive cohort, but the benefit of PI3K inhibitors has had limited success compared with approaches targeting other less common mutations. We found allelic imbalances in the expression of PIK3CA in normal breast tissue and mapped a germline candidate regulatory variant. An imbalance was also frequently observed in the ex...

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Literature Corpus work: 5a62cc1a-457c-5765-b664-1a7dc925a64c
DOI: 10.1101/2021.03.05.434137

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