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Beyond Tumors: Reduced survival linked to pathogenic<i>PIK3CA</i>and<i>TP53</i>post-zygotic variants in the uninvolved breast tissue of recurrent cancer patients

2024-10-04

Abstract excerpt

Histologically normal mammary tissue from breast cancer patients can harbor significant genetic alterations. We analyzed the spectrum of DNA variants in 408 matched histologically normal tissue and tumors from 77 poor-prognosis patients, 49 patients recruited without prognosis bias, and mammary gland samples from 15 non-cancerous individuals. Whole exome sequencing revealed a higher prevalence of pathogenic post-z...

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Literature Corpus work
2d783c12-70e1-5c9a-847c-fe114f35d471
DOI
10.1101/2024.10.04.24313634
Open publication

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Beyond Tumors: Reduced survival linked to pathogenic<i>PIK3CA</i>and<i>TP53</i>post-zygotic variants in the uninvolved breast tissue of recurrent cancer patientsDOI 10.1101/2024.10.04.24313634
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