Article

Clinicogenomic landscape and function of<i>PIK3CA</i>,<i>AKT1</i>, and<i>PTEN</i>mutations in breast cancer

2025-06-18

Abstract excerpt

<h4>Purpose</h4> To comprehensively characterize the clinical and genomic landscapes of PIK3CA, AKT1, and PTEN alterations and examine their functional implications in AKT-driven breast cancer. <h4>Experimental Design</h4> Comprehensive genomic profiling of 51,767 breast tumors was performed with FoundationOne ® CDx or FoundationOne ® . We examined the genomic landscape of PIK3CA , PTEN , and AKT1 alterations and...

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Literature Corpus work: ea5d1919-7d22-59ef-96fc-7efea0907c05
DOI: 10.1101/2025.06.18.25329632

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