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Article

Genomic dissection and mutation-specific target discovery for breast cancer PIK3CA hotspot mutations.

BMC genomics - 27 May 2024

Miranda Adam X, Kemp Justin, Davidson Brad A, Bellomo Sara Erika, Miranda Verda E, Manoni Alexandra, Marchiò Caterina, Croessmann Sarah, Park Ben H, Hodges Emily

Abstract excerpt

BACKGROUND: Recent advancements in high-throughput genomics and targeted therapies have provided tremendous potential to identify and therapeutically target distinct mutations associated with cancers. However, to date the majority of targeted therapies are used to treat all functional mutations within the same gene, regardless of affected codon or phenotype. RESULTS: In this study, we developed a functional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38802751
DOI: 10.1186/s12864-024-10368-1
PMCID: PMC11129441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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