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Article

Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients.

Nature communications - 10 Apr 2018

Chen Li, Yang Liu, Yao Ling, Kuang Xia-Ying, Zuo Wen-Jia, Li Shan, Qiao Feng, Liu Yi-Rong, Cao Zhi-Gang, Zhou Shu-Ling, Zhou Xiao-Yan, Yang Wen-Tao, Shi Jin-Xiu, Huang Wei, Hu Xin, Shao Zhi-Ming

Abstract excerpt

Deregulation of the phosphoinositide 3-kinase (PI3K) pathway contributes to the development and progression of tumors. Here, we determine that somatic mutations in PIK3CA (44%), PIK3R1 (17%), AKT3 (15%), and PTEN (12%) are prevalent and diverse in Chinese breast cancer patients, with 60 novel mutations identified. A high proportion of tumors harbors multiple mutations, especially PIK3CA plus PIK3R1 mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29636477
DOI: 10.1038/s41467-018-03867-9
PMCID: PMC5893593

Genes

AKT3
PTEN

Provenance

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