Article
PIK3CA Mutations are Common in Many Tumor Types and are Often Associated With Other Driver Mutations.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2000
Stachler Matthew D, Rinehart Elizabeth M, Garcia Elizabeth, Lindeman Neal I
Abstract excerpt
OBJECTIVES: Genotyping clinical cancer specimens determines a fuller spectrum of mutations that an individual tumor harbors, and thus provides better insight into its molecular pathogenesis. Using genotyping data collected during routine clinical care our objective was to better determine the genomic landscape associated with PIK3CA mutations since much interest has been placed on PIK3CA targeted therapy....
Topics
- Biomarkers, Tumor
- Class I Phosphatidylinositol 3-Kinases
- Humans
- Mutation
- Neoplasms
- Phosphatidylinositol 3-Kinases