Article

Copy number-independent allelic imbalance in mRNA is selected in cancer and has prognostic relevance

2024-09-09

Abstract excerpt

Allelic imbalance (AI) in levels of mRNAs in cancer is widely appreciated to result from somatic copy number alterations (CNA) affecting one allele. Apart from CNA, other mechanisms could lead to imbalanced mRNA expression of the alleles, and similarly drive cancer evolution by epistatic interactions with the somatic mutations. By integrating genomic and transcriptomic pan-cancer data, we show that mRNA allelic im...

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Literature Corpus work: 7aca0d91-fd1e-5630-bfde-07c5eb14ad3b
DOI: 10.1101/2024.09.07.611780

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