Article

Monoallelic expression characterizes a distinct molecular and clinical group of breast tumors

2026-02-17

Abstract excerpt

<title>Abstract</title> <p>In diploid cells, allelic imbalance occurs when gene alleles are expressed at different levels. To investigate the allelic imbalance landscape in tumor samples, we developed Interval-Based Allelic Imbalance Detection (IB-Aid), a quantitative framework that uses interval arithmetic to robustly distinguish monoallelic from biallelic gene expression by computing confidence intervals that a...

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Literature Corpus work: 2e42dbaf-7dcc-566d-91cb-c9cdc1287e72
DOI: 10.21203/rs.3.rs-8535132/v1

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