Article

Multiple DNA repair pathways prevent acetaldehyde-induced mutagenesis in yeast

2024-01-08

Abstract excerpt

Acetaldehyde is the primary metabolite of alcohol and is present in many environmental sources including tobacco smoke. Acetaldehyde is genotoxic, whereby it can form DNA adducts and lead to mutagenesis. Individuals with defects in acetaldehyde clearance pathways have increased susceptibility to alcohol-associated cancers. Moreover, a mutation signature specific to acetaldehyde exposure is widespread in alcohol an...

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Literature Corpus work: 59df30c6-38d4-5efa-9365-23fd94dd3b85
DOI: 10.1101/2024.01.07.574575

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