Article
Long-term exposure to the ethanol-derived metabolite acetaldehyde elevates structural genomic alterations but not base substitutions.
Communications biology - 17 Jan 2026
Lózsa Rita, Szikriszt Bernadett, Németh Eszter, Szeltner Zoltán, Martinek Regina, Póti Ádám, Feik Timóteus, Kollarics Sándor, Márkus Bence G, Kanu Nnennaya, Sztupinszki Zsófia, Simon Ferenc, Shibata Tatsuhiro, Swanton Charles, Szallasi Zoltan, Richardson Andrea L, Szüts Dávid
Abstract excerpt
Acetaldehyde is the primary metabolite of ethanol, and routes of exposure include endogenous sources, food and cigarette smoke. To explore whether the mutagenic effect of acetaldehyde is responsible for the carcinogenicity of ethanol, we use whole genome sequencing on four human cell lines subjected to long-term, physiologically relevant, analytically validated acetaldehyde treatments. Unexpectedly, the...
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