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Article

Effects of ethanol and acetaldehyde on multi-organ genomic mutation landscapes.

Cell biology and toxicology - 20 Jun 2026

Chavanel Bérénice, Tibaldi Eva, Virard François, Carreira Christine, Senkin Sergey, Abedi-Ardekani Behnoush, Cahais Vincent, Korenjak Michael, Herceg Zdenko, Balbo Silvia, Mandrioli Daniele, Zavadil Jiri

Abstract excerpt

Alcohol consumption is a major risk factor for cancer, particularly of the head and neck. Acetaldehyde, the main ethanol metabolite, is linked to oral carcinogenesis, but the mechanisms are not well understood. While some mutational signatures such as single-base substitution signature SBS16, doublet-base substitution signature DBS4, and indel signature ID11 have been linked to alcohol use, they are not limited...

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Topics

Animals
Acetaldehyde
Ethanol
Mutation
Male
Rats

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Rats, Inbred F344

Carcinogenesis

Genome

Source

Open in PubMed Open full text

Identifiers

PMID: 42321443
DOI: 10.1007/s10565-026-10217-9
PMCID: PMC13526727

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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