Article

Genome-scale multi-organ analysis of mutagenic effects of ethanol and acetaldehyde in Sprague Dawley rats

2025-09-07

Abstract excerpt

<h4>ABSTRACT</h4> Alcohol consumption is a major cancer risk factor, particularly for head and neck cancers, including the oral cavity. Acetaldehyde, the primary genotoxic metabolite of ethanol, may play key roles in oral carcinogenesis, though the mechanisms remain unclear. While mutational signatures SBS16, DBS4, and ID11 have been tentatively linked to alcohol use, they are not exclusive to alcohol-related can...

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Literature Corpus work: 217ba9ff-4ce0-5129-b312-e7816dae5468
DOI: 10.1101/2025.09.01.673482

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