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FANCD2 limits acetaldehyde‐induced genomic instability during DNA replication in esophageal keratinocytes

30 Jul 2021

Abstract excerpt

Individuals with Fanconi anemia (FA), a rare genetic bone marrow failure syndrome, have an increased risk of young-onset head and neck squamous cell carcinomas (SCCs) and esophageal SCC. The FA DNA repair pathway is activated upon DNA damage induced by acetaldehyde, a chief alcohol metabolite and one of the major carcinogens in humans. However, the molecular basis of acetaldehyde-induced genomic instability in...

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PMID: 34328261
DOI: 10.1002/1878-0261.13072

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