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Article

ER-directed TREX1 limits cGAS activation at micronuclei.

Molecular cell - 18 Feb 2021

Mohr Lisa, Toufektchan Eléonore, von Morgen Patrick, Chu Kevan, Kapoor Aakanksha, Maciejowski John

Abstract excerpt

Micronuclei are aberrant nuclear compartments that can form as a result of chromosome mis-segregation. Frequent loss of micronuclear envelope integrity exposes DNA to the cytoplasm, leading to chromosome fragmentation and immune activation. Here, we use micronuclei purification to show that the endoplasmic reticulum (ER)-associated nuclease TREX1 inhibits cGAS activation at micronuclei by degrading micronuclear...

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Identifiers

PMID: 33476576
DOI: 10.1016/j.molcel.2020.12.037
PMCID: PMC7897315

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