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Article

TREX1 exonuclease in immunity and disease

29 Jun 2025

Abstract excerpt

Three-prime repair exonuclease 1 (TREX1) is the major 3' to 5' DNA exonuclease in mammals and plays an essential role in preserving immune homeostasis by controlling cytosolic DNA sensing. By degrading excess self and foreign DNA, TREX1 limits aberrant activation of the cGAS-STING (cyclic GMP-AMP synthase - stimulator of interferon genes) pathway and downstream type I interferon responses. Loss-of-function...

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Identifiers

PMID: 40627703
DOI: 10.1093/intimm/dxaf037

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