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Article

TREX1 as a Novel Immunotherapeutic Target

1 Apr 2021

Abstract excerpt

Mutations in the TREX1 3' → 5' exonuclease are associated with a spectrum of autoimmune disease phenotypes in humans and mice. Failure to degrade DNA activates the cGAS-STING DNA-sensing pathway signaling a type-I interferon (IFN) response that ultimately drives immune system activation. TREX1 and the cGAS-STING DNA-sensing pathway have also been implicated in the tumor microenvironment, where TREX1 is proposed...

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PMID: 33868310
DOI: 10.3389/fimmu.2021.660184

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