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Article

cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing.

Molecular cell - 18 Feb 2021

Zhou Wen, Mohr Lisa, Maciejowski John, Kranzusch Philip J

Abstract excerpt

Cyclic GMP-AMP synthase (cGAS) recognition of cytosolic DNA is critical for the immune response to cancer and pathogen infection. Here, we discover that cGAS-DNA phase separation is required to resist negative regulation and allow efficient sensing of immunostimulatory DNA. We map the molecular determinants of cGAS condensate formation and demonstrate that phase separation functions to limit activity of the...

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Identifiers

PMID: 33606975
DOI: 10.1016/j.molcel.2021.01.024
PMCID: PMC7899126

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