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Article

TREX1 - Apex predator of cytosolic DNA metabolism.

DNA repair - 1 Oct 2020

Simpson Sean R, Hemphill Wayne O, Hudson Teesha, Perrino Fred W

Abstract excerpt

The cytosolic Three prime Repair EXonuclease 1 (TREX1) is a powerful DNA-degrading enzyme required for clearing cytosolic DNA to prevent aberrant inflammation and autoimmunity. In the absence of TREX1 activity, cytosolic DNA pattern recognition receptors of the innate immune system are constitutively activated by undegraded TREX1 substrates. This triggers a chronic inflammatory response in humans expressing...

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Identifiers

PMID: 32615442
DOI: 10.1016/j.dnarep.2020.102894
PMCID: PMC7985832

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