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Article

Structural basis of human TREX1 DNA degradation and autoimmune disease.

Nature communications - 25 Jul 2022

Zhou Wen, Richmond-Buccola Desmond, Wang Qiannan, Kranzusch Philip J

Abstract excerpt

TREX1 is a cytosolic DNA nuclease essential for regulation of cGAS-STING immune signaling. Existing structures of mouse TREX1 establish a mechanism of DNA degradation and provide a key model to explain autoimmune disease, but these structures incompletely explain human disease-associated mutations and have limited ability to guide development of small-molecule therapeutics. Here we determine crystal structures of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35879334
DOI: 10.1038/s41467-022-32055-z
PMCID: PMC9314330

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