Article

Aberrant gliogenesis and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids

2020-11-19

Abstract excerpt

MEF2C has been shown to be a critical transcription factor for neurodevelopment, whose loss-of-function mutation in humans results in MEF2C haploinsufficiency syndrome (MHS), a severe form of autism spectrum disorder (ASD)/intellectual disability (ID). Here, we use patient hiPSC-derived cerebrocortical neurons and cerebral organoids to characterize MHS deficits. Unexpectedly, we found an aberrant micro-RNA-mediate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 59d39454-431b-5d08-a1ee-c178675bc75a
DOI: 10.1101/2020.11.19.387639

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aberrant gliogenesis and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoidsDOI 10.1101/2020.11.19.387639Read

Enhancer-targeted CRISPR-A rescues haploinsufficiency and mutant phenotypes in organoid models of autismSemantic proximity Read

NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.Semantic proximity Read

Complete Disruption of Autism-Susceptibility Genes by Gene-Editing Predominantly Reduces Functional Connectivity of Isogenic Human NeuronsSemantic proximity Read

GABA/Glutamate neuron differentiation imbalance and increased AKT/mTOR signalling in CNTNAP2 <sup>-/-</sup> cerebral organoidsSemantic proximity Read

Excitation-Inhibition Imbalance Underlies Perioperative Neurocognitive Disorders: A Single-Nucleus Transcriptomic Perspective in Mice HippocampusSemantic proximity Read

Inhibition of the neurodevelopmental disorder-associated 16p11.2 gene <i>QPRT</i> leads to altered cell type distribution in human stem cell-derived cerebral organoidsSemantic proximity Read

Cortical Overgrowth in a Preclinical Forebrain Organoid Model of <i>CNTNAP2</i> -Associated Autism Spectrum DisorderSemantic proximity Read

Direct targets of <i>MEF2C</i> are enriched for genes associated with schizophrenia and cognitive function and are involved in neurogenesis and mitochondrial functionSemantic proximity Read

Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cerebral organoidsSemantic proximity Read

Integrative Single-Cell Analysis of Autism Spectrum Disorder Animal Models Reveal Convergent Transcriptomic Dysregulation Involved in Excitatory-Inhibitory Imbalance and Glial DisfunctionSemantic proximity Read

Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCsSemantic proximity Read

<i>CNTN5</i> <sup>−/+</sup> or <i>EHMT2</i> <sup>−/+</sup> iPSC-Derived Neurons from Individuals with Autism Develop Hyperactive Neuronal NetworksSemantic proximity Read