Article

<i>CNTN5</i> <sup>−/+</sup> or <i>EHMT2</i> <sup>−/+</sup> iPSC-Derived Neurons from Individuals with Autism Develop Hyperactive Neuronal Networks

2018-07-14

Abstract excerpt

Induced pluripotent stem cell (iPSC)-derived cortical neurons are increasingly used as a model to study developmental aspects of Autism Spectrum Disorder (ASD), which is clinically and genetically heterogeneous. To study the complex relationship of rare (penetrant) variant(s) and common (weaker) polygenic risk variant(s) to ASD, “isogenic” iPSC-derived neurons from probands and family-based controls, for modeling,...

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Literature Corpus work: db01664f-9a93-55ba-b1f3-342a4898819d
DOI: 10.1101/368928

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