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Integrative Single-Cell Analysis of Autism Spectrum Disorder Animal Models Reveal Convergent Transcriptomic Dysregulation Involved in Excitatory-Inhibitory Imbalance and Glial Disfunction

2025-05-06

Abstract excerpt

<h4>ABSTRACT</h4> Autism Spectrum Disorder (ASD) presents profound clinical and etiological heterogeneity, complicating the identification of core pathophysiological mechanisms. Single-cell RNA sequencing (scRNA-seq) offers cellular resolution but integrating findings across diverse studies remains challenging. Here, we constructed a unified single-cell reference framework by integrating scRNA-seq data from 11 di...

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Literature Corpus work: 229522f6-184c-50cd-967f-1f485132eca5
DOI: 10.1101/2025.05.05.651905

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