Back to search

Article

Direct targets of <i>MEF2C</i> are enriched for genes associated with schizophrenia and cognitive function and are involved in neurogenesis and mitochondrial function

2023-12-08

Abstract excerpt

Myocyte Enhancer Factor 2C ( MEF2C ) is a transcription factor that plays a crucial role in neurogenesis and synapse development. Genetic studies have identified MEF2C as a gene that influences cognition and risk for neuropsychiatric disorders, including autism spectrum disorder (ASD) and schizophrenia (SCZ). Here, we investigated the involvement of MEF2C in these phenotypes using human-derived neural stem cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
aabe14f4-f037-5d3d-a6f3-9f068876c8bf
DOI
10.1101/2023.12.07.570529
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Direct targets of <i>MEF2C</i> are enriched for genes associated with schizophrenia and cognitive function and are involved in neurogenesis and mitochondrial functionDOI 10.1101/2023.12.07.570529
Direct targets of MEF2C are enriched for genes associated with schizophrenia and cognitive function and are involved in neuron development and mitochondrial function.Semantic proximity
Genes influenced by MEF2C contribute to neurodevelopmental disease via gene expression changes that affect multiple types of cortical excitatory neuronsSemantic proximity
Genes positively regulated by Mef2c in cortical neurons are enriched for common genetic variation associated with IQ and educational attainment.Semantic proximity
Loss of <i>MEF2C</i> function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in miceSemantic proximity
CRISPR-engineered deletion of <i>POGZ</i> alters transcription factor binding at promoters of genes involved in synaptic signalingSemantic proximity
Single-cell dissection of schizophrenia reveals neurodevelopmental-synaptic axis and transcriptional resilienceSemantic proximity
MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice.Semantic proximity
Transcriptional and functional consequences of alterations to <i>MEF2C</i> and its topological organization in neuronal modelsSemantic proximity
Mendelian Randomization Study Using Dopaminergic Neuron-Specific eQTL Identifies Novel Risk Genes for Schizophrenia.Semantic proximity
Direct pathway bias and altered striatal neurogenesis in human iPSC models of 16p11.2 CNVs: Evidence from single-cell and functional analysesSemantic proximity
The novel lncRNA <i>lnc-NR2F1</i> is pro-neurogenic and mutated in human neurodevelopmental disordersSemantic proximity
Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan McDermid syndrome and autismSemantic proximity
Select a neighboring publication to make it the new centre.