Article

Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cerebral organoids

2024-08-10

Abstract excerpt

<h4>Summary</h4> Human cerebral organoids derived from induced pluripotent stem cells can recapture early developmental processes and reveal changes involving neurodevelopmental disorders. Mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene are associated with Rett syndrome, and disease severity varies depending on the location and type of mutation. Here, we focused on neuronal activity in Rett sy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f38ee1f8-a93b-5e5c-817d-706007150cb1
DOI: 10.1101/2024.08.10.607464

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cerebral organoidsDOI 10.1101/2024.08.10.607464Read

Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cortical organoids.Semantic proximity Read

Molecular and Functional Dysregulations in Novel, Rett Syndrome Patient-Derived Cerebral OrganoidsSemantic proximity Read

Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations.Semantic proximity Read

Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated <i>MECP2</i> mutationsSemantic proximity Read

MECP2T203M mutation disrupts neurogenesis in human cerebral organoids by altering chromatin dynamics and transcriptional regulation.Semantic proximity Read

Identification of neural oscillations and epileptiform changes in human brain organoidsSemantic proximity Read

Patient brain organoids identify a link between the 16p11.2 copy number variant and the <i>RBFOX1</i> geneSemantic proximity Read

Modeling Rett Syndrome with Human Pluripotent Stem Cells: Mechanistic Outcomes and Future Clinical Perspectives.Semantic proximity Read

Epigenetic Dysregulation in Rett Syndrome: Multisystem Pathophysiology, MECP2 Isoform-Specific Mechanisms, and Targeted Therapeutic StrategiesSemantic proximity Read

Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical OrganoidsSemantic proximity Read

Mecp2 deletion results in profound alterations of developmental and adult functional connectivitySemantic proximity Read