Article

Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs

2020-11-12

Abstract excerpt

<h4>ABSTRACT</h4> Fragile X syndrome (FXS) is a neurodevelopmental disorder, characterized by intellectual disability and sensory deficits, caused by epigenetic silencing of the FMR1 gene and subsequent loss of its protein product, fragile X mental retardation protein (FMRP). Delays in synaptic and neuronal development in the cortex have been reported in FXS mouse models, however, the main goal of translating la...

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Literature Corpus work: 64279304-3b09-5183-9757-2e0a55a576e1
DOI: 10.1101/2020.11.12.379800

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