Article

Complete Disruption of Autism-Susceptibility Genes by Gene-Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons

2018-06-11

Abstract excerpt

<h4>Summary</h4> Autism Spectrum Disorder is phenotypically and genetically heterogeneous, but genomic analyses have identified candidate susceptibility genes. We present a CRISPR gene editing strategy to insert a protein tag and premature termination sites creating an induced pluripotent stem cell (iPSC) knockout resource for functional studies of 10 ASD-relevant genes ( AFF2/FMR2, ANOS1, ASTN2, ATRX , CACNA1C...

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Literature Corpus work: 1ece5071-f287-5e50-8524-e6ebf35eba4c
DOI: 10.1101/344234

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