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Inhibition of the neurodevelopmental disorder-associated 16p11.2 gene <i>QPRT</i> leads to altered cell type distribution in human stem cell-derived cerebral organoids

2025-09-09

Abstract excerpt

<h4>Summary</h4> The 16p11.2 gene QPRT , encoding a key enzyme of the kynurenine pathway, has been linked to neurodevelopmental disorders including autism spectrum disorder (ASD). To investigate its role in early human brain development, we inhibited QPRT in stem cell-derived cerebral organoids. QPRT inhibition resulted in reduced organoid size, driven by premature neural differentiation resulting in depleted pr...

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Literature Corpus work
bc925827-ab28-532d-be3e-0219e55f2014
DOI
10.1101/2025.09.08.673916
Open publication

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Inhibition of the neurodevelopmental disorder-associated 16p11.2 gene <i>QPRT</i> leads to altered cell type distribution in human stem cell-derived cerebral organoidsDOI 10.1101/2025.09.08.673916
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