NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.

doi:10.1038/s41467-017-01563-8

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Article

NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.

Nature communications - 14 Nov 2017

Tu Shichun, Akhtar Mohd Waseem, Escorihuela Rosa Maria, Amador-Arjona Alejandro, Swarup Vivek, Parker James, Zaremba Jeffrey D, Holland Timothy, Bansal Neha, Holohan Daniel R, Lopez Kevin, Ryan Scott D, Chan Shing Fai, Yan Li, Zhang Xiaofei, Huang Xiayu, Sultan Abdullah, McKercher Scott R, Ambasudhan Rajesh, Xu Huaxi, Wang Yuqiang, Geschwind Daniel H, Roberts Amanda J, Terskikh Alexey V, Rissman Robert A, Masliah Eliezer, Lipton Stuart A, Nakanishi Nobuki

Abstract excerpt

Transcription factor MEF2C regulates multiple genes linked to autism spectrum disorder (ASD), and human MEF2C haploinsufficiency results in ASD, intellectual disability, and epilepsy. However, molecular mechanisms underlying MEF2C haploinsufficiency syndrome remain poorly understood. Here we report that Mef2c +/-(Mef2c-het) mice exhibit behavioral deficits resembling those of human patients. Gene expression...

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PMID: 29133852
DOI: 10.1038/s41467-017-01563-8
PMCID: PMC5684358

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