Cognitive resilience to Alzheimer’s disease in mice depends on gene-diet interactions

Abstract excerpt

Alzheimer’s disease (AD) has a complex etiology arising from largely unknown interactions between genetic and environmental (GxE) factors. Even in populations with causal familial Alzheimer’s disease mutations, there is variation in disease onset and progression, suggesting that clinical symptoms are modified by genetics and environment. Identification of such modifiers is critical, as mechanisms that promote resi...

Topics

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• Alzheimer Disease
• Alzheimer's disease research and treatments
• Binding Sites
• Cognition
• Disease Models, Animal
• Mice
• Mice, Transgenic
• Nuclear Receptors and Signaling

Identifiers and source

Literature Corpus work

592a9d5c-275c-5688-af36-36a4a394c5c2

DOI

10.1101/2025.02.07.637137