Genetic diversity promotes resilience in a mouse model of Alzheimer's disease.

doi:10.1002/alz.13753

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Article

Genetic diversity promotes resilience in a mouse model of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2024

Soni Neelakshi, Hohsfield Lindsay A, Tran Kristine M, Kawauchi Shimako, Walker Amber, Javonillo Dominic, Phan Jimmy, Matheos Dina, Da Cunha Celia, Uyar Asli, Milinkeviciute Giedre, Gomez-Arboledas Angela, Tran Katelynn, Kaczorowski Catherine C, Wood Marcelo A, Tenner Andrea J, LaFerla Frank M, Carter Gregory W, Mortazavi Ali, Swarup Vivek, MacGregor Grant R, Green Kim N

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disorder with multifactorial etiology, including genetic factors that play a significant role in disease risk and resilience. However, the role of genetic diversity in preclinical AD studies has received limited attention. METHODS: We crossed five Collaborative Cross strains with 5xFAD C57BL/6J female mice to generate F1 mice with and without the 5xFAD...

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Identifiers

PMID: 38426371
DOI: 10.1002/alz.13753
PMCID: PMC11032575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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