Article

Systems genetics identifies modifiers of Alzheimer’s disease risk and resilience

2017-11-27

Abstract excerpt

<h4>Summary</h4> Identifying genes that modify symptoms of Alzheimer’s disease (AD) will provide novel therapeutic strategies to prevent, cure or delay AD. To discover genetic modifiers of AD, we combined a mouse model of AD with a genetically diverse reference panel to generate F1 mice harboring identical ‘high-risk’ human AD mutations but which differ across the remainder of their genome. We first show that gen...

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Literature Corpus work: 26fa9fb1-382a-50b3-9cab-bac0d03a0127
DOI: 10.1101/225714

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