Article
Genetic variation in the Nr1d1 transcription factor binding site shapes metabolism-related protein networks associated with cognitive resilience in an Alzheimer's disease mouse reference panel.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2025
Chen Yu, Stevenson Tamara K, Cao Yiding, Fish Lauren A, Robbins Julia E, Merrihew Gennifer E, Park Jea, Hohman Timothy J, MacCoss Michael J, Kaczorowski Catherine C
Abstract excerpt
INTRODUCTION: Our previous work established the AD-BXD mouse panel as an innovative model for studying the genetic complexity and heterogeneity underlying Alzheimer's disease (AD). In this study, we leveraged this model and proteomics approach to identify protein signatures linked to cognitive resilience in AD. METHODS: We assessed cognitive performance in 6-month-old AD-BXD mice using contextual fear...
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