Hippocampus Glutathione S Reductase Potentially Confers Genetic Resilience to Cognitive Decline in the AD-BXD Mouse Population

Abstract excerpt

Alzheimer’s disease (AD) is a prevalent and costly age-related dementia. Heritable factors account for 58-79% of variation in late-onset AD, but substantial variation remains in age-of- onset, disease severity, and whether those with high-risk genotypes acquire AD. To emulate the diversity of human populations, we utilized the AD-BXD mouse panel. This genetically diverse resource combines AD genotypes with multipl...

Topics

Open a Topic to create a Post that cites this publication.

• Alzheimer Disease
• Binding Sites
• Cognition
• Disease Models, Animal
• Mice
• Mice, Transgenic
• Proteomics
• Quantitative Trait Loci

Identifiers and source

Literature Corpus work

387ed8d0-02c8-5b1c-95ec-ca056cc3a0a6

DOI

10.1101/2024.01.09.574219