Article

Gene dosage determines the behavioural phenotype in the 5xFAD mouse model of Alzheimer’s disease: analysis of the contribution of brain insulin signalling and gut microbiota

2022-09-30

Abstract excerpt

<title>Abstract</title> <bold>Background:</bold> There are many hypotheses about the neuropathological origin of sporadic Alzheimer’s disease (AD). The amyloid cascade hypothesis remains the most widely accepted by the scientific community, although the role of amyloid-β (Aβ) as the sole cause of neuropathological features of the non-inherited form of AD is questionable. <bold>Methods:</bold> The 5xFAD mouse m...

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Literature Corpus work: b2ec39a2-385b-595c-9c9d-c943ef417fc3
DOI: 10.21203/rs.3.rs-2087511/v1

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