Article

HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics

2020-10-09

Abstract excerpt

Chromatin, which consists of DNA and associated proteins, contains genetic information and is a mechanical component of the nucleus. Heterochromatic histone methylation controls nucleus and chromosome stiffness, but the contribution of heterochromatin protein HP1α (CBX5) is unknown. We used a novel HP1α auxin-inducible degron human cell line to rapidly degrade HP1α. Degradation did not alter transcription, local c...

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Literature Corpus work: 59233998-c065-5cb4-b517-c8cebf00a7f0
DOI: 10.1101/2020.10.09.331900

Open publication

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