Article

True-to-scale DNA-density maps correlate with major accessibility differences between active and inactive chromatin

2022-03-23

Abstract excerpt

<h4>Summary</h4> Chromatin compaction differences may have a strong impact on accessibility of individual macromolecules and macromolecular assemblies to their DNA target sites. Estimates based on fluorescence microscopy with conventional resolution, however, suggested only modest compaction differences (∼2-10x) between active and inactive nuclear compartments (ANC and INC). Here, we present maps of nuclear lands...

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Literature Corpus work: 5bbefa96-c223-53e8-94f2-a1b5f4f07c05
DOI: 10.1101/2022.03.23.485308

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