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Article

HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.

Nature - 29 May 2008

Ayoub Nabieh, Jeyasekharan Anand D, Bernal Juan A, Venkitaraman Ashok R

Abstract excerpt

Minutes after DNA damage, the variant histone H2AX is phosphorylated by protein kinases of the phosphoinositide kinase family, including ATM, ATR or DNA-PK. Phosphorylated (gamma)-H2AX-which recruits molecules that sense or signal the presence of DNA breaks, activating the response that leads to repair-is the earliest known marker of chromosomal DNA breakage. Here we identify a dynamic change in chromatin that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18438399
DOI: 10.1038/nature06875

Genes

ATM
ATR
CBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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