Article

Large-scale manipulation of radial positioning does not affect most aspects of genome organization

2024-08-23

Abstract excerpt

Although the spatial organization of the genome is closely linked to biological function, genome structure is highly stochastic. Within this heterogeneity, specific function-associated structural elements must be maintained, even when the nucleus is deformed due to physiological physical constraints. The radial positioning of genomic loci - their distance from the nuclear periphery - has long been considered an im...

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Literature Corpus work: 0f242c06-42e0-58cf-bd5e-878cbde00e09
DOI: 10.1101/2024.08.22.609170

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