Article

Depletion of lamins B1 and B2 alters chromatin mobility and induces differential gene expression by a mesoscale-motion dependent mechanism

2023-06-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> B-type lamins are critical nuclear envelope proteins that interact with the 3D genomic architecture. However, identifying the direct roles of B-lamins on dynamic genome organization has been challenging as their joint depletion severely impacts cell viability. To overcome this, we engineered mammalian cells to rapidly and completely degrade endogenous B-type lamins using Aux...

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Literature Corpus work: 412fa688-27a7-57bf-9d8b-cc99eb8914e8
DOI: 10.1101/2023.06.26.546573

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