Article

iCodon: ideal codon design for customized gene expression

2021-06-21

Abstract excerpt

<title>Abstract</title> <p>Messenger RNA (mRNA) stability substantially impacts steady-state gene expression levels in a cell. mRNA stability, in turn, is strongly affected by codon composition in a translation dependent manner across species, through a mechanism termed codon optimality. We have developed iCodon (www.iCodon.org), an algorithm for customizing mRNA expression through the introduction of synonymous...

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Literature Corpus work: 5050de82-853a-512d-bb18-8d44ab5df9ad
DOI: 10.21203/rs.3.rs-598844/v1

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